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Fourth-generation hydrofluorocarbon (HFC) replacements are developed to address environmental concerns associated with traditional HFCs. These next-generation refrigerants, primarily composed of hydrofluoroolefins (HFOs) and other low global warming potential (GWP) substances, offer significantly reduced environmental impact while maintaining high performance in cooling applications.

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HFO-1234ze(E) is a fourth generation HFC replacement.


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HFO-1233yd is a fourth-generation, low-GWP HFC replacement. Its POCP is 8—lower than ethane’s 11.5—indicating minimal involvement in photochemical reactions and little potential to cause air pollution.


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HFO-1234ze(Z) is a fourth generation HFC replacement.


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HFO-1234yf is the fourth-generation environmentally friendly refrigerant. It replaces R-134a and is used in automotive air-conditioning systems. While mainly used in the MVAC industry


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HFO-1336mzz(E) is a fourth generation HFC substitute with low GWP and low ODP.


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HFO-1233zd(Z) is a fourth generation HFC replacement.


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3,3,3-Trifluoropropyne



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HFO-1132(Z)


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